After being discharged from the Army, Brian Flanagan moves back to Queens and takes a job in a bar run by Doug Coughlin, who teaches Brian the fine art of bar-tending. Brian quickly becomes a patron favorite with his flashy drink-mixing style, and Brian adopts his mentor's cynical philosophy on life and goes for the money.
Young graduate student Jane Chase becomes the new assistant to an eccentric zoology professor at the remote home he shares with two brilliant chimpanzees and an elderly orangutan butler named Link. But when one of the chimps is found dead and the professor mysteriously disappears, Link becomes dangerously aggressive towards Jane. Now, the time for “monkey business” is over and the true terror is about to begin.
Cocky researcher Sebastian Caine is working on a project to make living creatures invisible. Determined to achieve the ultimate breakthrough, Caine pushes his team to move to the next phase — using himself as the subject. The test is a success, but when the process can't be reversed and Caine seems doomed to future without flesh, he starts to turn increasingly dangerous.
Canaan, a mysterious gunfighter left nearly blind from Civil War combat, roams through Mexico with a baby he has sworn to protect. On his way to a town where a family will supposedly adopt the baby, Canaan passes through a border town where U.S. Cavalry officers assigned to deliver a shipment of silver are under attack from bandits. With some reluctance, Canaan steps in to help the soldiers.